1. Epacadostat

Epacadostat (Synonyms: INCB 024360)

目录号: HY-15689 纯度: 99。65%

Epacadostat (INCB 024360) 是一种有效,选择性的 IDO1 抑制剂, IC50 为 71.8 nM±17.5 nM。

MCE 的所有产品仅用作科学研究,我们不为任何个人用途提供产品和服务

Epacadostat Chemical Structure

Epacadostat Chemical Structure

CAS No. : 1204669-58-8

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内


3.  试用装只面向终端客户

Size Price Stock Quantity
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ¥771 In-stock
2 mg ¥550 In-stock
5 mg ¥800 In-stock
10 mg ¥1000 In-stock
50 mg ¥3100 In-stock
100 mg ¥5000 In-stock
200 mg ¥8500 In-stock
500 mg ¥18000 In-stock
1 g ¥28000 In-stock
2 g ¥33000 In-stock
5 g   Get quote  
10 g   Get quote  

* Please select Quantity before adding items.

Customer Review

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的科研文献

    Epacadostat purchased from MCE. Usage Cited in:

    Western blot analysis of IDO1 protein levels for IFN-γ-stimulated HeLa cells that are treated with indicated compounds (e.g., Epacadostat).

    View All Indoleamine 2,3-Dioxygenase (IDO) Isoform Specific Products:

    • 生物活性

    • 实验参考方法

    • 技术信息

    • 纯度 & 产品资料

    • 参考文献


    Epacadostat (INCB 024360) is a potent and selective indoleamine 2,3-dioxigenase 1 (IDO1) inhibitor with an IC50 of 71.8 nM.

    IC50 & Target[1]


    71.8 nM (IC50)

    In Vitro

    In cellular assays, Epacadostat (INCB 024360) selectively inhibits human IDO1 with IC50 values of approximately 10 nM, demonstrating little activity against other related enzymes such as IDO2 or tryptophan 2,3-dioxygenase (TDO). Epacadostat (INCB 024360) also exhibits significant activity toward mouse IDO1, with an IC50 value of 52.4 nM±15.7 nM, in a similar assay using mouse IDO1-transfected HEK293/MSR cells[1].

    In Vivo

    Female Balb/c mice bearing CT26 tumors are treated orally twice daily for 12 d with Epacadostat at 100 mg/kg. Epacadostat (INCB 024360) suppresses kynurenine equivalently in plasma, tumors, and lymph nodes. In naïve C57BL/6 mice, 50 mg/kg Epacadostat (INCB 024360) decreases plasma kynurenine levels within 1 hour and those levels stay at least 50% suppressed through the 8-hour time course[2].

    Clinical Trial
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 31 mg/mL (70.74 mM)

    * "≥" means soluble, but saturation unknown.

    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.2819 mL 11.4095 mL 22.8191 mL
    5 mM 0.4564 mL 2.2819 mL 4.5638 mL
    10 mM 0.2282 mL 1.1410 mL 2.2819 mL
    In Vivo:
    • 1.

      INCB 024360 (Epacadostat) is dissolved freshly in sodium citrate buffer prior to each experiment[3].

    • [1].



    Cell Assay

    To determine Epacadostat activity against IDO in recombinant cells, HEK293/MSR cells are transiently transfected with full-length human or mouse IDO1, or mouse IDO2 cDNA, with Transit-293 transfection reagent or Lipofectamine 2000 reagents. Epacadostat (INCB 024360) at different concentrations is added to the recovered transfected cells seeded at 2×104 cells per well in a 96-well plate (200 μL/well). The cells are incubated for 2 days, and kyn in the supernatants is measured as described in the HeLa cell assay. The tryptophan 2,3-dioxygenase (TDO) assay is performed similarly with HEK293/MSR cells transfected with a human TDO expression vector[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Administration

    The female C57BL/6 mice are dosed orally with 50 mg/kg Epacadostat. C57BL/6 wild-type or Ido1-/--deficient mice are administered a single oral dose of Epacadostat (INCB 024360), at which point food is removed from the cages until after the 8-h time point. At various time points after dosing, mice are euthanized and blood is collected by cardiac puncture. Plasma is analyzed for the presence of Epacadostat (INCB 024360), tryptophan, and kynurenine according to the methods below.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    • [1].



    Molecular Weight




    CAS No.





    Room temperature in continental US; may vary elsewhere

    Purity: 99.65%

    • [1].



    • 摩尔计算器

    • 稀释计算器

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2


    Your information is safe with us. * Required Fields.



    * 需求量:

    * 客户姓名:


    * Email:

    * 电话:


    * 公司或机构名称:


    Bulk Inquiry

    Inquiry Information



    Cat. No.: HY-15689

    江苏快3 江苏快三 江苏快三 江苏快三 江苏快三 江苏快3 江苏快三 江苏快三 江苏快三 江苏快三