1. Signaling Pathways
  2. NF-κB
  3. NF-κB

NF-κB

NF-κB (Nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA。 NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens。 NF-κB plays a key role in regulating the immune response to infection。 Incorrect regulation of NF-κB has been linked to cancer, inflammatory, and autoimmune diseases, septic shock, viral infection, and improper immune development。 NF-κB has also been implicated in processes of synaptic plasticity and memory。 There are five proteins in the mammalian NF-κB family: NF-κB1, NF-κB2, RelA, RelB, c-Rel。

NF-κB Isoform Specific Products:

  • NF-κB

  • NF-κB1/p50

  • RelA/p65

  • RelB

Cat. No. Product Name Effect Purity
  • HY-13453
    BAY 11-7082 Inhibitor 99.42%
    BAY 11-7082是 NF-κB 抑制剂, 其通过抑制TNF-α诱导的IκB-α磷酸化来降低NF-κB。 BAY 11-7082抑制泛素化蛋白酶 USP7USP21IC50 分别为0.19 μM 和 0.96 μM。
  • HY-18738
    Pyrrolidinedithiocarbamate ammonium Inhibitor 99.86%
    Pyrrolidinedithiocarbamate ammonium是选择性的 NF-κB 抑制剂。
  • HY-P0151
    SN50 Inhibitor
    SN50是可渗透细胞的 NF-κB 易位抑制剂。
  • HY-32735
    Triptolide Inhibitor 99.83%
    Triptolide是从雷公藤根中提取的二萜类三环氧化物,具有免疫抑制,抗炎和抗增殖作用。 雷公藤内酯是 NF-κB 活化的抑制剂。
  • HY-N0822
    Shikonin Inhibitor 99.80%
    Shikonin是中草药紫草的主要成分。 Shikonin显示出各种生物活性,包括抑制TNF-αNF-κBHIV-1
  • HY-14621
    Zingerone Inhibitor 99.41%
    Zingerone (Vanillylacetone) 是一种无毒的甲氧基苯酚,从生姜中得到,具有抗炎、抗糖尿病、抗脂质过敏、抗腹泻、抗痉挛和抗肿瘤等活性。Zingerone 能够缓解氧化应激和炎症,下调 NF-κB 介导的信号通路。Zingerone 作为抗有丝分裂剂,能够抑制神经母细胞瘤的生长。
  • HY-N0708
    Vanillic acid Inhibitor >98.0%
    Vanillic acid 是一种在食用植物和水果中发现的调味剂。Vanillic acid 抑制 NF-κB 活化。具有抗炎,抗菌等活性。
  • HY-N1380
    Guaiacol Inhibitor 99.29%
    Guaiacol 是一种从愈创木树脂分离的酚类化合物,抑制 LPS 刺激的 COX-2 表达和 NF-κB 激活。具有抗炎活性。
  • HY-10257
    BAY 11-7085 Inhibitor 99.98%
    BAY 11-7085是NF-κB激活和IκBα磷酸化的抑制剂,稳定IκBα的IC50值为10 μM。
  • HY-13982
    JSH-23 Inhibitor 99.48%
    JSH-23是 NF-κB 抑制剂,抑制NF-κB转录活性,IC50 为7.1 μM。
  • HY-19356
    Rocaglamide Inhibitor
    Rocaglamide是一种有效的 NF-κB 活化抑制剂。
  • HY-N0176
    Dihydroartemisinin Inhibitor 99.03%
    Dihydroartemisinin是一种有效的抗疟疾 (anti-malaria) 药物。
  • HY-N2149
    Tomatidine Inhibitor >98.0%
    Tomatidine 通过阻断 NF-κBJNK 信号发挥抗炎作用。
  • HY-14655
    Sulfasalazine Inhibitor 99.42%
    Sulfasalazine是治疗类风湿关节炎和溃疡性结肠炎的药物。报道显示Sulfasalazine可抑制 NF-κB 的活性。
  • HY-14645
    (-)-DHMEQ Inhibitor 98.72%
    (–)-DHMEQ 是一种有效的 NF-κB inhibitor。
  • HY-13812
    QNZ Inhibitor 98.46%
    QNZ (EVP4593) 强抑制 NF-κB 转录激活和 TNF-α 产生,IC50 分别为 11 和 7 nM。QNZ (EVP4593) 是一种保护神经的钙池操纵的钙通道 (SOC) 抑制剂。
  • HY-N0197
    Baicalin Inhibitor 98.01%
    Baicalin 是一种从 Scutellaria baicalensis 中分离出来的类黄酮糖苷。Baicalin 降低 NF-κB 表达。
  • HY-N0141
    Parthenolide Inhibitor 99.88%
    Parthenolide是在药草短舌匹菊中发现的倍半萜内酯。 Parthenolide通过抑制 NF-κB 活化而表现出抗炎活性; 它还可抑制 HDAC1 蛋白而不影响其他I/II类HDAC。
  • HY-10074
    TPCA-1 Inhibitor 99.54%
    TPCA-1 是一种有效,选择性的 IKK-2 抑制剂,IC50 值为 17.9 nM。TPCA-1 也是STAT3NF-kB 的直接抑制剂。
  • HY-13010
    Laquinimod Inhibitor 99.84%
    Laquinimod是一种有效的免疫调节剂,可预防中枢神经系统的神经变性和炎症。

NF-κB transcription factors are critical regulators of immunity, stress responses, apoptosis and differentiation. In mammals, there are five members of the transcription factor NF-κB family: RELA (p65), RELB and c-REL, and the precursor proteins NF-κB1 (p105) and NF-κB2 (p100), which are processed into p50 and p52, respectively. NF-κB transcription factors bind as dimers to κB sites in promoters and enhancers of a variety of genes and induce or repress transcription. NF-κB activation occurs via two major signaling pathways: the canonical and the non-canonical NF-κB signaling pathways[1]

 

The canonical NF-κB pathway is triggered by signals from a large variety of immune receptors, such as TNFR, TLR, and IL-1R, which activate TAK1。 TAK1 then activates IκB kinase (IKK) complex, composed of catalytic (IKKα and IKKβ) and regulatory (NEMO) subunits, via phosphorylation of IKKβ。 Upon stimulation, the IKK complex, largely through IKKβ, phosphorylates members of the inhibitor of κB (IκB) family, such as IκBα and the IκB-like molecule p105, which sequester NF-κB members in the cytoplasm。 IκBα associates with dimers of p50 and members of the REL family (RELA or c-REL), whereas p105 associates with p50 or REL (RELA or c-REL)。 Upon phosphorylation by IKK, IκBα and p105 are degradated in the proteasome, resulting in the nuclear translocation of canonical NF-κB family members, which bind to specific DNA elements, in the form of various dimeric complexes, including RELA-p50, c-REL-p50, and p50-p50。 Atypical, IKK-independent pathways of NF-κB induction also provide mechanisms to integrate parallel signaling pathways to increase NF-κB activity, such as hypoxia, UV and genotoxic stress。

 

The non-canonical NF-κB pathway is induced by certain TNF superfamily members, such as CD40L, BAFF and lymphotoxin-β (LT-β), which stimulates the recruitment of TRAF2, TRAF3, cIAP1/2 to the receptor complex. Activated cIAP mediates K48 ubiquitylation and proteasomal degradation of TRAF3, resulting in stabilization and accumulation of the NFκB-inducing kinase (NIK). NIK phosphorylates and activates IKKα, which in turn phosphorylates p100, triggering p100 processing, and leading to the generation of p52 and the nuclear translocation of p52 and RELB[2][3].

 

Reference:

[1]. Oeckinghaus A, et al. The NF-kappaB family of transcription factors and its regulation.Cold Spring Harb Perspect Biol. 2009 Oct;1(4):a000034. 
[2]. Taniguchi K, et al. NF-κB, inflammation, immunity and cancer: coming of age. Nat Rev Immunol. 2018 May;18(5):309-324.
[3]. Perkins ND,et al. Integrating cell-signalling pathways with NF-kappaB and IKK function. Nat Rev Mol Cell Biol. 2007 Jan;8(1):49-62.

Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

江苏快三 江苏快3 江苏快3 江苏快三 江苏快3 江苏快三 江苏快三 江苏快3 江苏快3 江苏快3