1. Signaling Pathways
  2. Membrane Transporter/Ion Channel
  3. Na+/Ca2+ Exchanger

Na+/Ca2+ Exchanger

Na+/Ca2+ exchanger (sodium-calcium exchanger , NCX) is an antiporter membrane protein that removes calcium from cells. It uses the energy that is stored in the electrochemical gradient of sodium (Na+) by allowing Na+ to flow down its gradient across the plasma membrane in exchange for the countertransport of calcium ions (Ca2+). Na+/Ca2+ exchanger removes a single calcium ion in exchange for the import of three sodium ions. Na+/Ca2+ exchanger exists in many different cell types and animal species. Na+/Ca2+ exchanger is considered one of the most important cellular mechanisms for removing Ca2+. The Na+/Ca2+ exchanger does not bind very tightly to Ca2+ (has a low affinity), but it can transport the ions rapidly (has a high capacity), transporting up to five thousand Ca2+ ions per second. The Na+/Ca2+ exchanger also likely plays an important role in regaining the cell's normal calcium concentrations after an excitotoxic insult.

Na+/Ca2+ Exchanger 相关产品 (8):

Cat. No. Product Name Effect Purity
  • HY-15415
    KB-R7943 mesylate Inhibitor 99.39%
    KB-R7943 mesylate 是一种 Na+/Ca2+ 交换体 (NCXrev) 反向抑制剂,IC50 为 5.7±2.1 µM。
  • HY-15515
    SEA0400 Inhibitor 99.97%
    SEA0400 是一种新颖的,具有选择性的 Na+-Ca2+ exchanger 抑制剂,在培养的神经元、星形胶质细胞和小胶质细胞中,能够抑制 Na+-依赖性 Ca2+ 的吸收,IC50 值为 5-33 nM。
  • HY-15754
    CGP37157 Inhibitor 99.79%
    CGP37157 是一种 Na+/Ca2+ exchanger 抑制剂,可抑制豚鼠心脏线粒体 Na+ 诱导的 Ca2+ 的释放,IC50 值为 0.8 μM。
  • HY-107658
    SN 6 Inhibitor >99.0%
    SN 6 是一种选择性的 NCX 抑制剂,可抑制 NCX1,NCX2 和 NCX3 对 45Ca2+ 的吸收,IC50 值分别为 2.9,16 和 8.6 μM。
  • HY-123785
    ORM-10962 Inhibitor
    ORM-10962 是有效的、高度选择性的钠钙交换器 (NCX) 抑制剂,对正向反向模式抑制的 IC50 值分别为 67 nM 和 55 nM。
  • HY-128678
    ORM-10103 Inhibitor
    ORM-10103 是 Na+/Ca2+ 交换体 (NCX) 特异性的抑制剂,ORM-10103 降低了 NCX 电流,在 -80 和 20 mV 下的 IC50 的估算值分别为 55 和 67 nM。
  • HY-19062
    SM-6586 Inhibitor
    SM-6586 是一种 calcium channel 的拮抗剂,同时能够抑制 Na+/H+Na+/Ca2+ exchange transport,主要用于研究脑血管疾病和高血压等疾病。
  • HY-100298
    Caldaret Inhibitor
    Caldaret 是一种细胞内 Ca2+ 调节剂,通过反向模式抑制 Na+/Ca2+ 交换作用。
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