1. Signaling Pathways
  2. Apoptosis
  3. c-Myc

c-Myc

c-Myc is the master transcription factor for cell proliferation and is involved in numeroushematological and solidcancers。

Proto-oncogene c-Myc, encoding one of the most important transcription factors, plays a pivotal role in tumor initiation and progression. c-Myc regulates hundreds of disparate target genes that participate numerous biological effects, such as cell proliferation, apoptosis, differentiation, and stem cell self-renewal. c-Myc is one of the four factors used in reprogramming somatic cells to induce pluripotent stem (iPS) cells and is implicated in maintaining cancer stem-like cells (CSCs).

The transcription factor c-Myc is a key mediator of the Notch signaling–regulated T cell differentiation. In a well-established in vitro differentiation model of T lymphocytes from hematopoietic stem cells, Notch1 and 4 directly promotes c-Myc expression; dominant-negative (DN) c-Myc inhibits early T cell differentiation. Moreover, the c-Myc expression activated by Notch signaling increases the expression of survivin, an inhibitor of apoptosis (IAP) protein.

c-Myc gene, as a transcription factor of hTERT, is over expressed in a variety of tumors.c-Myc and hTERT expression in local recurrent gastric cancer tissues is much higher than in primary gastric cancer tissues at the protein and mRNA levels.

c-Myc 相关产品 (7):

Cat. No. Product Name Effect Purity
  • HY-12702
    10058-F4 Inhibitor 99.92%
    10058-F4是 c-Myc 抑制剂,其阻止c-Myc-Max二聚化和c-Myc靶基因表达的反式激活。
  • HY-19735
    KJ Pyr 9 Inhibitor 99.25%
    KJ Pyr 9 是 MYC 的抑制剂。体外实验中, KJ Pyr 9 抑制 MYC 的 Kd 值为 6.5±1.0 nM。
  • HY-103038
    ML327 Inhibitor 98.04%
    ML327 是 MYC 的阻断剂,也可以去阻遏 E-钙粘蛋白转录和逆转上皮-间质转化 (EMT)。
  • HY-100669
    Mycro 3 Inhibitor 98.63%
    Mycro 3 是一种有效的选择性 c-Myc 抑制剂。
  • HY-100996
    10074-G5 Inhibitor
    10074-G5是c-Myc-Max二聚化抑制剂,IC50值为146 μM。
  • HY-111411
    IZCZ-3 Inhibitor
    IZCZ-3 是有效的 c-MYC 转录抑制剂,具有抗肿瘤活性。
  • HY-12703
    KSI-3716 Inhibitor
    KSI-3716是 c-Myc 的抑制剂。
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately。

江苏快3 江苏快三 江苏快三 江苏快三 江苏快3 江苏快三 江苏快三 江苏快3 江苏快3 江苏快三