1. Signaling Pathways
  2. GPCR/G Protein
    Neuronal Signaling
  3. mAChR

mAChR

mAChRs (muscarinic acetylcholine receptors) are acetylcholine receptors that form G protein-receptor complexes in the cell membranes of certainneurons and other cells. They play several roles, including acting as the main end-receptor stimulated by acetylcholine released from postganglionic fibersin the parasympathetic nervous system. mAChRs are named as such because they are more sensitive to muscarine than to nicotine. Their counterparts are nicotinic acetylcholine receptors (nAChRs), receptor ion channels that are also important in the autonomic nervous system. Many drugs and other substances (for example pilocarpineand scopolamine) manipulate these two distinct receptors by acting as selective agonists or antagonists. Acetylcholine (ACh) is a neurotransmitter found extensively in the brain and the autonomic ganglia.

mAChR 相关产品 (116):

Cat. No. Product Name Effect Purity
  • HY-B0726
    Pilocarpine Hydrochloride Agonist 99.92%
    Pilocarpine Hydrochloride 是一种选择性的 M3 型毒蕈碱乙酰胆碱受体 (M3 muscarinic receptor) 激动剂。
  • HY-N0296A
    Scopolamine hydrobromide Antagonist >98.0%
    Scopolamine hydrobromide 是高亲和力的 (nM 级别) 毒蕈碱 (muscarinic) 拮抗剂。Scopolamine 可逆抑制 5-HT3 受体反应,IC50 为 2.09 μM。
  • HY-B1208
    Carbamoylcholine chloride Agonist >98.0%
    Carbamoylcholine氯化物用来研究nAChR和mAchR的介导的反应, 包括平滑肌收缩, 肠运动, 与神经信号。Carbamoylcholine是乙酰胆碱类似物, 激活乙酰胆碱受体 (AChR), Carbamoylcholine是nAChR和mAchR受体激动剂, 针对不同的受体, Ki值为10到10,000 nM。
  • HY-B0394
    Atropine sulfate monohydrate Antagonist 99.62%
    Atropine硫酸一水合物是毒蕈碱乙酰胆碱受体拮抗剂。
  • HY-B1205
    Atropine Antagonist 99.55%
    Atropine主要用于治疗一些神经毒剂或农药中毒、心率减缓等症状,以及在外科手术中减少唾液的产生。
  • HY-120081A
    Metixene hydrochloride hydrate Inhibitor 99.85%
    Metixene hydrochloride hydrate 是一种抗胆碱能、抗帕金森剂,能够有效抑制二苯羟乙酸奎宁酯与毒蕈碱受体 (muscarinic receptor) 结合,IC50Kd 值分别为 55 nM 和 15 nM。
  • HY-112076
    Atropine methyl bromide Antagonist
    Atropine methyl bromide, 是毒蕈碱型受体 (mAChR) 的拮抗剂,是阿托品的季铵盐,是眼科检查时用于瞳孔扩张的药物。由于其高度极性,被用于缓解婴儿幽门痉挛。它比阿托品更不易进入中枢神经系统。
  • HY-105545
    Dexetimide Antagonist
    Dexetimide ((+)-Benzetimide) 是一种高亲和力的毒蕈碱受体拮抗剂,也是强效持久抗胆碱药,可用于治疗神经抑制性帕金森病。
  • HY-A0012
    Darifenacin hydrobromide Antagonist
    Darifenacin hydrobromide 是选择性M3蕈毒碱受体拮抗剂,pKi 为 8.9。
  • HY-B0106
    Levetiracetam Inhibitor 99.99%
    Levetiracetam (UCB L059) 是一种选择性 M2 毒蕈碱乙酰胆碱受体 (mAChR) 抑制剂。抗癫痫。
  • HY-B0489
    Arecoline hydrobromide Agonist >99.0%
    Arecoline氢溴酸盐是毒蕈碱乙酰胆碱受体(mAChR)激动剂。
  • HY-B0499A
    Otilonium bromide Inhibitor
    Otilonium溴化物有抗毒蕈碱活性,可用于解痉。
  • HY-112209
    VU0467154 Agonist 98.78%
    VU0467154 是一种 M4 毒蕈碱的乙酰胆碱受体 (M4 muscarinic acetylcholine receptor (mAChR)) 的正向调节剂,能够增强小鼠,人和食蟹猴 M4 受体对乙酰胆碱的反应,pEC50 值分别为 7.75,6.2 和 6。
  • HY-17037
    Pirenzepine dihydrochloride 99.65%
    Pirenzepine dihydrochloride (LS519) 是一种选择性 M1 型毒蕈碱受体拮抗剂。
  • HY-17465
    Glycopyrrolate Antagonist >98.0%
    Glycopyrrolate(Glycopyrronium Br)是竞争性毒蕈碱拮抗剂,可解痉挛。
  • HY-N0471
    L-Hyoscyamine Inhibitor 99.08%
    L-Hyoscyamine是莨菪烷生物碱,为阿托品的左旋同分异构体。
  • HY-A0083
    Methacholine chloride Agonist >98.0%
    Methacholine chloride是选择性毒蕈碱受体mAChR激动剂。
  • HY-A0034
    Solifenacin Antagonist 99.77%
    Solifenacin (YM905 free base) 是一种新型的毒蕈碱受体拮抗剂,对 M1M2M3 受体的 pKi 值分别为 7.6, 6.9 和 8.0。
  • HY-15885
    LY2119620 Agonist 99.74%
    LY2119620 是一种高亲和力的毒蕈碱性 M2/M4 受体激动剂。
  • HY-13204
    Biperiden Hydrochloride Inhibitor >98.0%
    Biperiden Hydrochloride (KL 373 Hydrochloride) 是M1胆碱受体阻断剂,可作用于帕金森症。
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