1. Signaling Pathways
  2. Stem Cell/Wnt
  3. sFRP-1


Secreted frizzled-related proteins (SFRPs) are soluble proteins that have highly restricted tissue distribution。 SFRPs are capable of binding to Wnts and frizzled (Fz) receptors to interfere with Wnt signaling, which plays a major role in cell fate determination through the regulation of cell proliferation, differentiation, and apoptosis。

sFRP-1 contributes to the inhibition of apoptosis in fibroblast populations。 sFRP-1 proteins are involved in apoptosis by negatively modulating wingless/int (WNT) signaling by interacting with either WNTs or Frizzled receptors。 By sequestering WNTs, sFRP-1 removes the stimulus for β-catenin stabilization and mediates various biological processes。

SFRP proteins modulate Wnt signalling by interacting with either Wnt or frizzled receptors and are reported to affect epithelial/stromal interactions in prostate cancer.

sFRP-1 相关产品 (1):

Cat. No. Product Name Effect Purity
  • HY-10858
    WAY 316606 Inhibitor 99.61%
    WAY 316606 是一种分泌蛋白 sFRP-1 抑制剂,是分泌性醣蛋白 Wnt 的拮抗剂,在 FP 结合检测使用中,WAY-316606 作用于 sFRP-1,IC50 为 0.5 μM。
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