1. LHF-535

LHF-535 

目录号: HY-112762
产品使用指南

LHF-535 是一种抗病毒剂,对 Lassa,Machupo,Junin,VSVg 病毒的 EC50 分别为 <1 μM,<1 μM,<1 μM 和 1-10 μM,详细信息请参考专利文献 WO2012006552A1 中的化合物 1。

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LHF-535 Chemical Structure

LHF-535 Chemical Structure

CAS No. : 1450929-77-7

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Size Price Stock Quantity
10 mM * 1 mL in DMSO ¥3850 In-stock
5 mg ¥3500 In-stock
10 mg ¥5500 In-stock
50 mg ¥16500 In-stock
100 mg ¥26500 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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Description

LHF-535 is an antiviral agent extracted from patent WO2013123215A2, Compound 38, has EC50s of <1 μM, <1 μM, <1 μM, and 1-10 μM for Lassa, Machupo, Junin, and VSVg virus, respectively[1].

In Vitro

LHF-535 is a small-molecule viral entry inhibitor that targets the arenavirus envelope glycoprotein (GP). LHF-535 exhibits potent antiviral activity against a broad array of hemorrhagic fever arenaviruses. LHF-535 inhibits Lassa GP-pseudotyped lentivirus with an IC50 of 0.1-0.3 nM[2].

In Vivo

LHF-535 (3, 10 or 30 mg/kg; orally; daily; 14 days) protectes mice from a lethal challenge with Tacaribe virus and dramatically reduces viral titers in plasma, spleen, and liver[2].
An increase in survival is also observed when the first dose of LHF-535 (10 mg/kg) is delayed by 1, 2, or 3 days after infection, demonstrating that LHF-535 is efficacious as a post-exposure therapeutic in mice[2].

Animal Model: IFN-α/β and-γ receptor-deficient AG129 mice[2]
Dosage: 3, 10, or 30 mg/kg/day
Administration: Orally; daily; 14 days
Result: Effective as a post-exposure therapeutic.
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 96.67 mg/mL (234.34 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4241 mL 12.1206 mL 24.2412 mL
5 mM 0.4848 mL 2.4241 mL 4.8482 mL
10 mM 0.2424 mL 1.2121 mL 2.4241 mL
* 请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液,并请注意储备液的保存方式和期限。
In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案,配制前请先配制澄清的储备液,再依次添加助溶剂 (为保证实验结果的可靠性,体内实验的工作
液,建议您现用现配,当天使用;澄清的储备液可以根据储存条件,适当保存;以下溶剂前的百分比是指该溶剂在您配制终溶液中的体积占比):

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.42 mg/mL (5.87 mM); Clear solution

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2。42 mg/mL (5。87 mM); Clear solution

*以上所有助溶剂都可在 MCE 网站选购。
References
  • [1].

    [2].

Molecular Weight

412.52

Formula

C₂₇H₂₈N₂O₂

CAS No.

1450929-77-7

SMILES

OC(C)(C)C1=CC=C(/C=C\C2=CC=C3C(N=CN3C4=CC=C(OC(C)C)C=C4)=C2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere

  • [1]。

    [2].

  • 摩尔计算器

  • 稀释计算器

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× = ×
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产品名称:
LHF-535
目录号:
HY-112762
需求量:

LHF-535

Cat。 No。: HY-112762

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