1. Protein Tyrosine Kinase/RTK
  2. TX1-85-1

TX1-85-1 

目录号: HY-100848 纯度: >98.0%
产品使用指南

TX1-85-1 是一种不可逆的 Her3 (ErbB3) 抑制剂,IC50 值为 23 nM,TX1-85-1 也是第一个选择性 Her3 配体,与位于 Her3 的 ATP 结合位点的 Cys721 形成共价键。TX1-85-1诱发 Her3 蛋白部分降解,并减弱 Her3 依赖性信号传导。

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TX1-85-1 Chemical Structure

TX1-85-1 Chemical Structure

CAS No. : 1603845-32-4

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Description

TX1-85-1 is an irreversible Her3 (ErbB3) inhibitor with an IC50 of 23 nM and is also the first selective Her3 ligand, which forms a covalent bond with Cys721 located in the ATP-binding site of Her3. TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling[1].

IC50 & Target[1]

ErbB3

23 nM (IC50)

In Vitro

TX1-85-1 possesses an anti-proliferation EC50s of 9.9, 11.5, and 16.9 μM for Ovcar8, HCC827 GR6, and PC9 GR4 cells, respectively[1].

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References
  • [1].

Molecular Weight

580.68

Formula

C₃₂H₃₆N₈O₃

CAS No.

1603845-32-4

SMILES

CC(N1CCN(C2CCC(N3N=C(C4=CC(NC(C=C)=O)=C(OC5=CC=CC=C5)C=C4)C6=C3N=CN=C6N)CC2)CC1)=O

Shipping

Room temperature in continental US; may vary elsewhere

Purity: >98.0%

  • [1].

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The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
TX1-85-1
目录号:
HY-100848
需求量:

TX1-85-1

Cat。 No。: HY-100848

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